abstract：AIMS:Accumulated evidence indicates that cerebral metabolic features, evaluated by proton magnetic resonance spectroscopy (1 H-MRS), are sensitive to early mitochondrion dysfunction associated with mitochondrial encephalomyopathy (ME). The metabolite ratios of lactate (lac)/Cr, N-acetyl aspartate (NAA)/creatine (Cr), t...

journal_title：CNS neuroscience & therapeutics

authors： Niu FN,Meng HL,Chang LL,Wu HY,Li WP,Liu RY,Wang HT,Zhang B,Xu Y

更新日期：2017-08-01 00:00:00

abstract：AIMS:Neuroinflammation contributed to the pathogenesis of multiple system atrophy (MSA). We aimed to detect the correlation between inflammatory mediators, such as Klotho (Klt), vitamin D (25(OH)D) and homocysteine (Hcy), and disease severity among MSA patients. METHODS:A total of 53 MSA patients, 65 PD patients, and ...

journal_title：CNS neuroscience & therapeutics

authors： Guo Y,Zhuang XD,Xian WB,Wu LL,Huang ZN,Hu X,Zhang XS,Chen L,Liao XX

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate the roles of autophagy and endoplasmic reticulum (ER) stress in intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI) in rats. METHODS:Autophagy inducer (rapamycin) and inhibitor (3-methyladenine), as well as ER stress activator (tunicamycin, TM) and inhibitor (tau...

journal_title：CNS neuroscience & therapeutics

authors： Duan XC,Wang W,Feng DX,Yin J,Zuo G,Chen DD,Chen ZQ,Li HY,Wang Z,Chen G

更新日期：2017-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is leading cause of death among older characterized by neurofibrillary tangles, oxidative stress, progressive neuronal deficits, and increased levels of amyloid-β (Aβ) peptides. Cholinergic treatment could be the best suitable physiological therapy for AD. Calcitonin gene-related peptide (CGRP...

journal_title：CNS neuroscience & therapeutics

authors： Singh Y,Gupta G,Shrivastava B,Dahiya R,Tiwari J,Ashwathanarayana M,Sharma RK,Agrawal M,Mishra A,Dua K

更新日期：2017-06-01 00:00:00

abstract：AIMS:Axonal degeneration is a pathological symbol in the early stage of Alzheimer's disease (AD), which can be triggered by amyloid-β (Aβ) peptide deposition. Growing evidence indicates that deficit of autophagy eventually leads to the axonal degeneration. Our previous studies have shown that Dendrobium nobile Lindl al...

journal_title：CNS neuroscience & therapeutics

authors： Li LS,Lu YL,Nie J,Xu YY,Zhang W,Yang WJ,Gong QH,Lu YF,Lu Y,Shi JS

更新日期：2017-04-01 00:00:00

abstract：AIMS:Bipolar disorder is characterized by behavioral changes such as risk-taking and increasing goal-directed activities, which may result from altered reward processing. Patients with bipolar disorder show impaired reward learning in situations that require the integration of reinforced feedback over time. In this stu...

journal_title：CNS neuroscience & therapeutics

authors： Ryu V,Ha RY,Lee SJ,Ha K,Cho HS

更新日期：2017-03-01 00:00:00

abstract：AIMS:Glutamatergic transmission may play a critical role in the pathogenesis of Parkinson's disease (PD). Electroacupuncture (EA) has been demonstrated to effectively alleviate PD symptoms. In this study, a potential glutamate-dependent mechanism underlying the therapeutic action of EA was investigated. METHODS:The ef...

journal_title：CNS neuroscience & therapeutics

authors： Jia YJ,Deng JH,Zhang WZ,Sun ZL,Yang J,Yu Y,Gong XL,Jia J,Wang XM

更新日期：2017-01-01 00:00:00

abstract：:Cysteinyl leukotrienes are a group of the inflammatory lipid molecules well known as mediators of inflammatory signaling in the allergic diseases. Although they are traditionally known for their role in allergic asthma, allergic rhinitis, and others, recent advances in the field of biomedical research highlighted the ...

journal_title：CNS neuroscience & therapeutics

authors： Ghosh A,Chen F,Thakur A,Hong H

更新日期：2016-12-01 00:00:00

abstract：AIM:To compare atomoxetine (ATX) length of therapy (LoT) among adults with ADHD who reached the recommended dose of 80 mg/day (ATX ≥ 80) versus those who did not (ATX < 80) analyzed separately in patients prescribed ATX as monotherapy (mono) and in combination with other ADHD medications (combo). METHODS:This was a re...

journal_title：CNS neuroscience & therapeutics

authors： Clemow DB,Nyhuis AW,Robinson RL

更新日期：2016-12-01 00:00:00

abstract：AIMS:In our previous study, eEF1A1 was identified to be a new target for protecting brain ischemia injury, but the mechanism remains largely unknown. In this study, we screened the downstream cellular protein molecules interacted with eEF1A1 and found mechanism of eEF1A1 in brain ischemia protection. METHODS AND RESUL...

journal_title：CNS neuroscience & therapeutics

authors： Liu Y,Jiang S,Yang PY,Zhang YF,Li TJ,Rui YC

更新日期：2016-10-01 00:00:00

abstract：AIMS:Spinocerebellar ataxia type 1 (SCA1) is caused by the ataxin-1 protein (ATXN1) with an abnormally expanded polyglutamine tract and is characterized by progressive neurodegeneration. We previously showed that intrathecal injection of mesenchymal stem cells (MSCs) during the nonsymptomatic stage mitigates the degene...

journal_title：CNS neuroscience & therapeutics

authors： Suto N,Mieda T,Iizuka A,Nakamura K,Hirai H

更新日期：2016-08-01 00:00:00

abstract：INTRODUCTION:Presence of white matter hyperintensity (WMH) on MRI is a marker of cerebral small vessel disease and is associated with increased small vessel stroke and increased risk of hemorrhagic transformation (HT) after thrombolysis. AIM:We sought to determine whether white matter hypoperfusion (WMHP) on perfusion...

journal_title：CNS neuroscience & therapeutics

authors： Bivard A,Cheng X,Lin LT,Levi C,Spratt N,Kleinig T,O'Brien B,Butcher K,Lou M,Zhang JF,Sylaja PN,Cao WJ,Jannes J,Dong Q,Parsons M

更新日期：2016-03-01 00:00:00

abstract：:Retinal degenerative diseases (RDs) such as retinitis pigmentosa (RP) are a genetically heterogeneous group of disorders characterized by night blindness and peripheral vision loss, which caused by the dysfunction and death of photoreceptor cells. Although many causative gene mutations have been reported, the final co...

journal_title：CNS neuroscience & therapeutics

authors： Furukawa A,Koriyama Y

更新日期：2016-01-01 00:00:00

abstract：AIMS:This study was designed to examine the neuroprotective effects of bakkenolide-IIIa, a major novel compound extracted from the rhizome of P. trichinous. METHODS:Transient focal cerebral damage model in rats and oxygen-glucose deprivation (OGD) in cultured hippocampal neurons were performed. The amount of apoptotic...

journal_title：CNS neuroscience & therapeutics

authors： Jiang Q,Li RP,Tang Y,Wang YQ,Liu C,Guo ML

更新日期：2015-12-01 00:00:00

abstract：AIMS:Recently, mutations in COQ2 encoding para-hydroxybenzoate-polyprenyl transferase have been identified to increase the risk of multiple system atrophy (MSA) in multiplex families and sporadic cases. The prevalence of COQ2 mutations was showed to be higher in cerebellar subtype (MSA-C) than parkinsonism subtype (MSA...

journal_title：CNS neuroscience & therapeutics

authors： Wen XD,Li HF,Wang HX,Ni W,Dong Y,Wu ZY

更新日期：2015-08-01 00:00:00

abstract：AIMS:The mouse model of allo-head and body reconstruction (AHBR) has recently been established to further the clinical development of this strategy for patients who are suffering from mortal bodily trauma or disease, yet whose mind remains healthy. Animal model studies are indispensable for developing such novel surgic...

journal_title：CNS neuroscience & therapeutics

authors： Ren XP,Ye YJ,Li PW,Shen ZL,Han KC,Song Y

更新日期：2015-08-01 00:00:00

abstract：:Stroke is a significant unmet clinical need. The current stroke treatment of tissue plasminogen activator is limited to the very acute 4.5 h after disease onset which benefits only less than 3% of ischemic stroke patients. Our overarching hypothesis advances the notion that gender, which has been established as a como...

journal_title：CNS neuroscience & therapeutics

authors： Pabón MM,Ji XM,Fernandez JW,Borlongan CV

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Patients with temporal lobe epilepsy (TLE) often suffer from comorbid psychiatric diagnoses such as depression, anxiety, or impaired cognitive performance. Endocannabinoid (eCB) signaling is a key regulator of synaptic neurotransmission and has been implicated in the mechanisms of epilepsy as well as sever...

journal_title：CNS neuroscience & therapeutics

authors： Ma L,Wang L,Yang F,Meng XD,Wu C,Ma H,Jiang W

更新日期：2014-10-01 00:00:00

abstract：AIM:Anticoagulants are commonly used to treat ischemic stroke. Its impact on cerebellar infarction has not been fully understood. METHODS:In the clinical study, we reviewed a consecutive series of patients with large-sized cerebellar infarction (diameter > 3 cm, n = 30) treated with or without anticoagulation. In anim...

journal_title：CNS neuroscience & therapeutics

authors： Zhang SQ,Wang W,Ma XL,Xia YY,Liu AJ

更新日期：2014-09-01 00:00:00

abstract：AIMS:To evaluate the health-related quality of life (HRQL) and its correlates in children and adolescents with narcolepsy. METHODS:We compared the clinical characteristics of control subjects and patients with primary narcolepsy from data collected at the National Reference Centers for Narcolepsy. RESULTS:The cohort ...

journal_title：CNS neuroscience & therapeutics

authors： Inocente CO,Gustin MP,Lavault S,Guignard-Perret A,Raoux A,Christol N,Gerard D,Dauvilliers Y,Reimão R,Bat-Pitault F,Lin JS,Arnulf I,Lecendreux M,Franco P

更新日期：2014-08-01 00:00:00

abstract：:Fingolimod is a sphingosine 1-phosphate (S1P) receptor modulator approved to treat relapsing-remitting multiple sclerosis (MS). Initiation of treatment with fingolimod has been found to produce transient bradycardia and/or slowing of atrioventricular impulse conduction in a small proportion of patients. This effect is...

journal_title：CNS neuroscience & therapeutics

authors： Vanoli E,Pentimalli F,Botto G

更新日期：2014-06-01 00:00:00

abstract：AIMS:To examine the relationship between statin use in Chinese patients with intracerebral hemorrhage (ICH) during their hospitalization and the outcomes. METHODS:Data were collected from the China National Stroke Registry. Good functional outcome was defined by a modified Rankin Scale score between 0-2. Functional ou...

journal_title：CNS neuroscience & therapeutics

authors： Pan YS,Jing J,Wang YL,Zhao XQ,Song B,Wang WJ,Wang D,Liu GF,Liu LP,Wang CX,Wang YJ,CNSR investigators.

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Sunitinib is an inhibitor of the multiple receptor tyrosine kinases (RTKs) for cancer therapy. Some sunitinib analogues could prevent neuronal death induced by various neurotoxins. However, the neuroprotective effects of sunitinib have not been reported. METHODS:Cerebellar granule neurons (CGNs) and SH-SY5Y...

journal_title：CNS neuroscience & therapeutics

authors： Cui W,Zhang ZJ,Hu SQ,Mak SH,Xu DP,Choi CL,Wang YQ,Tsim WK,Lee MY,Rong JH,Han YF

更新日期：2014-03-01 00:00:00

abstract：AIMS:The 24-week, prospective, randomized, double-blind ACTION study investigated the efficacy, safety, and tolerability of 13.3 versus 4.6 mg/24 h rivastigmine patch in patients with severe Alzheimer's disease (AD). METHODS:Patients had probable AD and Mini-Mental State Examination scores ≥3-≤12. Primary outcome meas...

journal_title：CNS neuroscience & therapeutics

authors： Farlow MR,Grossberg GT,Sadowsky CH,Meng X,Somogyi M

更新日期：2013-10-01 00:00:00

abstract：:Octodon degus (O. degus) is a diurnal rodent that spontaneously develops several physiopathological conditions, analogous in many cases to those experienced by humans. In light of this, O. degus has recently been identified as a very valuable animal model for research in several medical fields, especially those concer...

journal_title：CNS neuroscience & therapeutics

authors： Tarragon E,Lopez D,Estrada C,Ana GC,Schenker E,Pifferi F,Bordet R,Richardson JC,Herrero MT

更新日期：2013-09-01 00:00:00

abstract：AIMS:This study investigated the influence of sigma-1 receptor (σ1 R) deficiency on adult neurogenesis. METHODS:We employed 8-week-old male σ1 R knockout (σ1 R(-/-) ) mice to examine the proliferation and differentiation of progenitor cells, and the survival and neurite growth of newborn neurons in hippocampal dentate...

journal_title：CNS neuroscience & therapeutics

authors： Sha S,Qu WJ,Li L,Lu ZH,Chen L,Yu WF,Chen L

更新日期：2013-09-01 00:00:00

abstract：AIMS:Inflammation and apoptosis play important roles in increasing vascular permeability following subarachnoid hemorrhage (SAH). The objective of this study was to evaluate whether urinary trypsin inhibitor (UTI), a serine protease inhibitor, attenuates vascular permeability by its antiinflammatory and antiapoptotic e...

journal_title：CNS neuroscience & therapeutics

authors： Zhou N,Xu T,Bai Y,Prativa S,Xu JZ,Li K,Han HB,Yan JH

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:ATP-sensitive potassium (K-ATP) channels couple energy metabolism with electric activity, which play important roles in brain diseases including stroke. However, the impacts of Kir6.1-containing K-ATP channels that mainly expressed on glia in stroke remain unclear. METHODS AND RESULTS:In this st...

journal_title：CNS neuroscience & therapeutics

authors： Dong YF,Wang LX,Huang X,Cao WJ,Lu M,Ding JH,Sun XL,Hu G

更新日期：2013-08-01 00:00:00

abstract：AIM:Till date, the mode of action of β-PEA on neurons is not well illustrated. We tested the hypothesis that β-PEA has the ability to cause oxidative stress by inhibiting the antioxidant enzyme DT-diaphorase and mitochondrial complexes (Complex-I and complex-III). METHODS:Using molecular docking as a tool, we here stu...

journal_title：CNS neuroscience & therapeutics

authors： Mazumder MK,Paul R,Borah A

更新日期：2013-08-01 00:00:00

abstract：:Status epilepticus (SE), a neurological emergency both in adults and in children, could lead to brain damage and even death if untreated. Generalized convulsive SE (GCSE) is the most common and severe form, an example of which is that induced by organophosphorus nerve agents. First- and second-line pharmacotherapies a...

journal_title：CNS neuroscience & therapeutics

authors： Dorandeu F,Dhote F,Barbier L,Baccus B,Testylier G

更新日期：2013-06-01 00:00:00

abstract：AIMS:Endothelial progenitor cells (EPCs) are involved in vascular repair and homeostasis after vascular injuries. In this study, we aimed to explore whether bone marrow (BM)-derived EPCs contribute to neointima formation and reendothelialization in rabbit elastase-induced aneurysm after flow diverter treatment. METHOD...

journal_title：CNS neuroscience & therapeutics

authors： Li ZF,Fang XG,Yang PF,Huang QH,Zhao WY,Liang C,Zhao R,Liu JM

更新日期：2013-05-01 00:00:00

abstract：AIMS:The MS-275 is a selective inhibitor of class I histone deacetylases (HDACs), which has been reported as a potential strategy in some central nervous system diseases associated with neurodegeneration and disturbed learning. However, its role in traumatic brain injury is not well defined. In this study, we examined ...

journal_title：CNS neuroscience & therapeutics

authors： Cao P,Liang Y,Gao X,Zhao MG,Liang GB

更新日期：2013-05-01 00:00:00

abstract：AIMS:Prior studies have demonstrated the involvement of leptin and cannabinoids in food intake and metabolism. However, the interaction between leptin and cannabinoids in epilepsy has not been studied. This study elucidated the relationship between leptin and cannabinoids in penicillin-induced epileptiform activity in ...

journal_title：CNS neuroscience & therapeutics

authors： Arslan G,Alici SK,Ayyildiz M,Agar E

更新日期：2013-04-01 00:00:00

abstract：AIM:To examine the effects of combination with levamlodipine and bisoprolol on stroke in rats. METHODS:For acute study, Systolic blood pressure (SBP) and heart period (HP) were monitored in conscious stroke prone-spontaneously hypertensive rats (SHR-SP) and sinoaortic denervation (SAD) rats before and after intragastr...

journal_title：CNS neuroscience & therapeutics

authors： Gui H,Guo YF,Liu X,Zhang JM,Yang YL,Huang GZ,Liu JG

更新日期：2013-03-01 00:00:00

abstract：:Cerebral ischemia is a severe outcome that could cause cognitive and motor dysfunction, neurodegenerative diseases and even acute death. Although the existence of autophagy in cerebral ischemia is undisputable, the consensus has not yet been reached regarding the exact functions and influence of autophagy in cerebral ...

journal_title：CNS neuroscience & therapeutics

authors： Wei K,Wang P,Miao CY

更新日期：2012-11-01 00:00:00

abstract：AIMS:To conduct a large-scale analysis on epidemiology, management, and outcomes of spontaneous subarachnoid hemorrhage (SAH), and to investigate the current situation of aneurysm obliteration in China. METHODS:A multicenter prospective cohort study involving 132 hospitals throughout China from September 2007 to Augus...

journal_title：CNS neuroscience & therapeutics

authors： Bian LH,Liu YF,Nichols LT,Wang CX,Wang YL,Liu GF,Wang WJ,Zhao XQ

更新日期：2012-11-01 00:00:00

abstract：:Stroke is a leading cause of death that affects 15 million people worldwide each year. Increasing evidence suggests that stroke confers substantial risk for suicide and following a stroke, patients frequently develop poststroke depression, which is a well-established risk factor for suicide. In this overview of the cu...

journal_title：CNS neuroscience & therapeutics

authors： Pompili M,Venturini P,Campi S,Seretti ME,Montebovi F,Lamis DA,Serafini G,Amore M,Girardi P

更新日期：2012-09-01 00:00:00

abstract：:Research on the potential impact of high salt intake on health has grown rapidly over the last decades. Recent studies have suggested that high salt intake could also be associated with adverse effects on cardiovascular system. The review evaluated the current level of epidemiologic evidence on the association between...

journal_title：CNS neuroscience & therapeutics

authors： Li XY,Cai XL,Bian PD,Hu LR

更新日期：2012-08-01 00:00:00

abstract：AIMS:Depression is a highly prevalent disorder in the elderly and one of the risk factors for developing dementia. The present study involves patients with Alzheimer's disease (AD), geriatric major depressive disorder (MDD) and cognitively healthy controls aiming to compare baseline cerebrospinal fluid (CSF) biomarkers...

journal_title：CNS neuroscience & therapeutics

authors： Reis T,Brandão CO,Freire Coutinho ES,Engelhardt E,Laks J

更新日期：2012-07-01 00:00:00

abstract：AIMS:To investigate the incidence of depression at different time points within the first year after stroke in mainland China and to identify risk factors related to a poor 1-year prognosis in stroke patients. METHODS:Subjects with acute cerebrovascular diseases were recruited and enrolled from 56 hospitals in mainlan...

journal_title：CNS neuroscience & therapeutics

authors： Zhang N,Wang CX,Wang AX,Bai Y,Zhou Y,Wang YL,Zhang T,Zhou J,Yu X,Sun XY,Liu ZR,Zhao XQ,Wang YJ,Prospective Cohort study on Incidence and Outcome of Patients with Poststroke Depression in China (PRIOD) Investigators.

更新日期：2012-06-01 00:00:00